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刊登论文列表

以下是经Enago编辑润色后成功刊登在权威期刊的部分论文列表,不断更新中:
  • Motohiro Kato published in Nature
  • Janos published in Blood
  • Nishino Kunihiko published in Nature
  • Tanaka Tomoharu published in PLoS ONE
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胃肠手术

3.2 狭窄型克罗恩病的手术技巧

因克罗恩病的不可治愈性和以去除症状为目的原则,克罗恩病的外科治疗理念从广泛病变切除的“巨创”逐步演变为尽量保留肠管的“微创”。外科医师已逐渐开始摒弃克罗恩病因系膜肥厚、组织脆、腹腔连、手术难度大等陈旧思想,不断尝试腹腔镜克罗恩病手术[10]。近年来亦有手助腹腔镜、单孔腹腔镜、机器人辅助治疗克罗恩病的相关报道[11-13]。克罗恩病腹腔镜手术优势明显,同样具有美观、创伤小、恢复快等优点[14]。部分术后复发患者依然可以选择腹腔镜手术[15]。Bergamaschi等[16]对92例克罗恩病患者分别行腹腔镜和开腹回结肠切除术,其研究结果显示:腹腔镜手术组患者术后5年小肠梗阻发生率为11.1%,较开腹手术的35.4%明显降低,差异有统计学意义。但克罗恩病腹腔镜手术中转开腹率高是不争的事实,严格筛选手术适应证患者是避免中转开腹的关键。本研究中腹腔镜手术率低,中转开腹率高,这主要与笔者团队对腹腔镜肠道炎性疾病手术认识以及术前评估不够有关,部分复发再次手术患者术中腹腔粘连并没有术前预估的严重,可以通过腹腔镜完成手术。

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3.2 Surgical techniques in stricturing Crohn’s disease (CD)

Due to the incurable nature of CD and the alleviation of symptoms as the principle of treatment, the concept of surgical treatment of CD has been evolved from massive ablation of diseased area to minimally invasive surgery that reserves as much intestinal tract as possible. Surgeons have gradually abandoned the outdated concept that surgery on CD is difficult due to mesenteric hypertrophy, tissue fragility and abdominal adhesion, and continuously tried laparoscopic surgery on CD (10). Hand-assisted laparoscopy, single site laparoscopy, and robot-assisted surgery on treating CD have also been reported in recent years (11-13). The advantages of using laparoscopic surgery on CD are evident, with the same ones like pleasing appearance, small incision, and fast-recovery (14). Some patients with postoperative recurrence can still choose laparoscopic surgery (15). Bergamaschi et al. (16) compared 39 patients who underwent laparoscopic ileocolic resection with 53 patients who had open ileocolic resection, and found out that five-year small-bowel obstruction rates were 11.1 and 35.4%, respectively, in laparoscopic ileocolic resection and open ileocolic resection patients, and the difference was statistically significant. Nevertheless, the rate of switching to open abdomen surgery during laparoscopic surgery remains high. The key of prevention is strict screening of patients who are suitable for the procedure. In this study, the rate of laparoscopic surgery was low and that of switching to open abdomen surgery during laparoscopic surgery was high. This is mainly due to the fact that the author’s team did not have either a complete understanding of laparoscopic surgery on inflammatory bowel disease, or an adequate pre-surgery evaluation. In some patients with postoperative recurrence, the abdominal adhesion was less severe than pre-surgery evaluation, and they can still choose laparoscopic surgery.

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3.2 Surgical techniques in stricturing Crohn’s disease (CD)

Due to the incurable nature of CD and the alleviation of symptoms being the aim of treatment, the concept of surgical treatment for CD has evolved from massive ablation of the diseased area to minimally invasive surgery that reserves as much of the intestinal tract as possible. Surgeons have gradually abandoned the outdated concept that surgery for CD is difficult due to mesenteric hypertrophy, tissue fragility, and abdominal adhesion and have continuously attempted performing laparoscopic surgery for CD (10). The use of hand-assisted laparoscopy, single site laparoscopy, and robot-assisted surgery for treating CD has also been reported in recent years (11-13). The advantages of using laparoscopic surgery for CD are evident, and it also has benefits of pleasing appearance, small incision, and fast recovery (14). Some patients with postoperative recurrence can still choose to undergo laparoscopic surgery (15). Bergamaschi et al. (16) compared 39 patients who had undergone laparoscopic ileocolic resection with 53 patients who had undergone open ileocolic resection and found that five-year small bowel obstruction rates were 11.1 and 35.4% in patients who had undergone laparoscopic ileocolic resection and those who had undergone open ileocolic resection, respectively. This difference was statistically significant. Nevertheless, the rate of switching to open abdominal surgery during laparoscopic surgery remains high. The key to prevent this is the strict screening of patients who are suitable to undergo the procedure. In this study, the rate of laparoscopic surgery was low and that of switching to open abdominal surgery during laparoscopic surgery was high. This is mainly due to the fact that the author’s team did not have a complete understanding of laparoscopic surgery for inflammatory bowel disease or perform an adequate preoperative assessment. In some patients with postoperative recurrence, abdominal adhesion was less severe than that suggested by preoperative assessment, and the patients were able to choose laparoscopic surgery.